Levamisole-induced occlusive necrotising vasculitis in cocaine abusers: an unusual cause of skin necrosis and neutropenia.
نویسندگان
چکیده
We present three cases describing the various skin manifestations of presumed levamisole-contaminated cocaine use. Antibody-mediated vasculitis and neutropenia were consistent findings in these cases and repeat exposure resulted in distinct dermatologic complications. This phenomenon of levamisole-induced vasculitis and neutropenia is being increasingly described and has characteristic wound manifestations that must be recognised and treated early.
منابع مشابه
p-ANCA-Associated Vasculitis Caused by Levamisole-Adulterated Cocaine: A Case Report
A rare case of a patient with an unusual skin rash after using cocaine is presented. A clinical diagnosis of levamisole-induced vasculitis was made based on initial presentation of purpuric skin lesions involving the ears and positive cocaine on urine toxicology screening. The diagnosis was confirmed after laboratory findings of neutropenia, positive serum levamisole, and a histopathologic test...
متن کاملLevamisole-induced vasculitis with ecchymosis and necrosis syndrome from contaminated cocaine.
DESCRIPTION A 43-year-old-man presented with 1-month history of progressive erythematous painful lesions over multiple sites involving bilateral lower extremities, trunk and pinnae. He was a chronic cocaine user; last use was 3 days prior to presentation. On examination he had bilateral large retiform, geometric, dusky, erythematous, tender plaques with central necrosis and ecchymosis over afor...
متن کاملA Fatal Case of Levamisole-Induced Vasculitis
Levamisole is an antihelminthic agent used mainly by veterinarians that is now commonly used as an adulterant in cocaine [1]. Numerous case reports have connected levamisole with vasculitis and neutropenia [2, 3]. Our case focuses on a patient who used weekly cocaine contaminated with levamisole and developed necrosis of the skin in her lower extremities, abdomen, and lower back. To our knowled...
متن کاملCocaine-induced vasculitis with cutaneous manifestation: A recurrent episode after 2 years
Cocaine is a popular recreational drug in the United States, and up to 70% of the seized cocaine contains levamisole which is an antihelminthic that can cause cutaneous vasculitis with necrosis and positive antineutrophil cytoplasmic antibodies (ANCAs). Here, we report a unique case of recurrent cocaine-induced vasculitis in a patient who smokes cocaine for more than 20 years. A 38-year-old wom...
متن کاملClinical & Medical Imaging Title: Levamisole induced Vasculopathy: A Case of Extensive Necrosis after Re-exposure to Levamisole Tainted Cocaine
Levamisole induced skin vasculitis/vasculopathy is a relatively new diagnosis with limited knowledge about the underlying mechanism of above manifestation. The most commonly reported cause is the generation of autoantibodies against myleoperoxidase and other neutrophilic enzymes hence commonly mimicking ANCA associated vasculitis. We present a case report of 52 years old female with history of ...
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ورودعنوان ژورنال:
- International wound journal
دوره 10 5 شماره
صفحات -
تاریخ انتشار 2013